More on the special motif HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children https://t.co/LkYeQDn2kN Funny, the interferons and anitbodies don't neutralize..
This is indeed seen in SARS-CoV-2, specifically with MIS-C: https://t.co/AZARUXvXY9 But there is something that bothers me about the data we have re spike protein as a superantigen.
@fitterhappierAJ "...polyacidic residues in the Vβ chain encoded by TRBV11-2 (Vβ21.3) strongly interact with the superantigen-like motif of SARS-CoV-2 spike" https://t.co/83ozhYccyZ
JCI - HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children https://t.co/V71Fp72tuj
RT @yoncabulutmd: 2/3 🧵 Superantigen (SAg) like motif in #Covid19 spike protein may be causing toxic shock like presentation due to similar…
RT @yoncabulutmd: 2/3 🧵 Superantigen (SAg) like motif in #Covid19 spike protein may be causing toxic shock like presentation due to similar…
RT @yoncabulutmd: SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children HLA class I-associated expansion of TRBV11-…
RT @jclinicalinvest: Just Published: HLA class I-associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children:…
RT @ArditiMd: JCI Commentary published for our JCI article on SARS-CoV2 Superantigen in MIS-C , and expansion of TRBV11-2 T cells associate…
@villagerssn @KathMLee1 @Paul_Bogdanich Here are some of the papers that point to many of these things . The fact is that the jabs are basically autoimmunity and hyper inflammation in a vial. https://t.co/iBNq6iEBnb https://t.co/T8davroSLZ https://t.co/nG
@lovethebacchus @DogzHerdin @redboybroken @fitterhappierAJ This seems like a good article. I think it seems reasonable. A testable hypothesis is to see if you have clonal expansion of TCRVβ subpopulations. I did find later papers that suggest that this is
Data Reuse: Poritt et al., HLA class I-associated expansion of TRBV11-2 T cells in Multisystem Inflammatory Syndrome in Children, Journal of Clinical Investigations, Mar 2021, https://t.co/NTJmykgqeC
RT @jeffgilchrist: Researchers found that children with MIS-C, like people with toxic shock syndrome, have increased numbers of T cells wit…
RT @unimedhal: Die beiden Paper sind unter folgenden Links abrufbar (#FreeAccess): https://t.co/sAryFOhHgP und https://t.co/Gb8H2BJb6A
Die beiden Paper sind unter folgenden Links abrufbar (#FreeAccess): https://t.co/sAryFOhHgP und https://t.co/Gb8H2BJb6A
ומה הלאה? הגוף מתחיל לייצר נוגדנים כנגד התאים שלו. הם הצליחו להראות את זה בכמה שיטות, יש נזק לרקמות שונות https://t.co/gWdYVqtKi3 הם גם הראו בפרסום מאוחר יותר שיש נטיה גנטית של חלבוני MHC-I לMIS-C חמור: https://t.co/7mfy7iKWD5 (6/8) https://t.co/PkUJLjth9B
RT @jorgenponder: En T-cellsreceptor som verkar förvärra vid MIS-C är TCRβ variable gene 11-2 (TRBV11-2), enligt detta paper. Alla människ…
En T-cellsreceptor som verkar förvärra vid MIS-C är TCRβ variable gene 11-2 (TRBV11-2), enligt detta paper. Alla människor har inte den som jag förstår det: https://t.co/DiDf21t8NH
@zeynep @mugecevik @andrew_croxford @ChiefStevieP @justsomeoneDK @fitterhappierAJ As an example here. I found 2-3 others. The context is he was commenting on this paper and someone asked if he was referring to ADE. https://t.co/O0aenl0VcL https://t.co/mq4g
@ArditiMd @LeviHoste @FReichert667 @lizWWyld @apsmunro @Damian_Roland Very strong and important paper. Compliments to you and your team. https://t.co/1hp1nfUJm8
JCI - HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children https://t.co/ttnqhhJIIZ
Researchers found that children with MIS-C, like people with toxic shock syndrome, have increased numbers of T cells with a receptor that binds to superantigens ( https://t.co/N7SCwJ1TXK ). 16/
Children with MIS-C, like people with toxic shock syndrome, have increased numbers of T cells with a receptor that binds to superantigens. 4/ https://t.co/s75S3zWeMj
RT @yoncabulutmd: 2/3 🧵 Superantigen (SAg) like motif in #Covid19 spike protein may be causing toxic shock like presentation due to similar…
RT @LaelYonker: Very interesting: T cell clonal expansion in MISC- key insight into the hyperinflammatory response in kids post-COVID. The…
RT @jclinicalinvest: .@ArditiMd @CedarsSinai: T cell receptor repertoires in multisystem inflammatory syndrome in children: https://t.co/iM…
2)TRBV11-2⬆️;HLA class I alleles A02,B35,C04:CDR3-independ Tcell⬆️;polyacidic residues Vβ chain encode TRBV11-2(Vβ21.3)interact super Ag-RBM S glycoprotein-direct⬆️TRBV11-2;CDR3-independ interact(S+TCR)-Tcell⬆️activ-⬆️Cytokines MIS-C
HLA class I–asso.⬆️TRBV11-2 Tcells:MIS-C;hyperinflam.syndr.assowith SARSCoV2,like TSS,Super-Ag specif for diff Vβ chains-Vβ chains skewing,Tcells Ag-⬆️expr TCR repertoire,⬆️TCRβgene 11-2(TRBV11-2),24% clonal Tcell-TRBV11-2 Tcell.TRBJ gene,(CDR3) https://t.
RT @jclinicalinvest: .@ArditiMd @CedarsSinai: T cell receptor repertoires in multisystem inflammatory syndrome in children: https://t.co/iM…
Very interesting: T cell clonal expansion in MISC- key insight into the hyperinflammatory response in kids post-COVID. The plot thickens as TRBV11-2 closely correlates with superantigen-like S1 antigen found in the blood in MISC. https://t.co/qtNlRRClFc @A
.@ArditiMd @CedarsSinai: T cell receptor repertoires in multisystem inflammatory syndrome in children: https://t.co/iMFa6LWhST #COVID_19 #Immunology https://t.co/gf5nOjNQBc
RT @yoncabulutmd: 2/3 🧵 Superantigen (SAg) like motif in #Covid19 spike protein may be causing toxic shock like presentation due to similar…
RT @yoncabulutmd: 2/3 🧵 Superantigen (SAg) like motif in #Covid19 spike protein may be causing toxic shock like presentation due to similar…
RT @yoncabulutmd: 2/3 🧵 Superantigen (SAg) like motif in #Covid19 spike protein may be causing toxic shock like presentation due to similar…
RT @yoncabulutmd: 2/3 🧵 Superantigen (SAg) like motif in #Covid19 spike protein may be causing toxic shock like presentation due to similar…
2- We have already shown that TRBV11-2 (Vβ21.3) strongly interact with the superantigen-like motif of SARS-CoV-2 spike glycoprotein, suggesting that the shed S1 SARS-CoV-2 spike may directly mediate TRBV11-2 expansion. https://t.co/ccQ3pWd9QD
RT @yoncabulutmd: @areinamo21 @PIPSQC @ArditiMd @rekamlatina @JennaMillerKC @BrodinPetter @casanova_lab @ongsoomay I am not sure about KD n…
@areinamo21 @PIPSQC @ArditiMd @rekamlatina @JennaMillerKC @BrodinPetter @casanova_lab @ongsoomay I am not sure about KD numbers in Japan. Only 3 cases of #MISC from S. Korea. Very little Asian cases reported So #MISC is a different disease than KD and may
RT @jclinicalinvest: Just Published: SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children (MIS-C): https://t.co/Yb…
RT @jclinicalinvest: Just Published: SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children (MIS-C): https://t.co/Yb…
RT @ArditiMd: JCI Commentary published for our JCI article on SARS-CoV2 Superantigen in MIS-C , and expansion of TRBV11-2 T cells associate…
RT @yoncabulutmd: SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children HLA class I-associated expansion of TRBV11-…
RT @jclinicalinvest: Just Published: SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children (MIS-C): https://t.co/Yb…
RT @jclinicalinvest: Just Published: SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children (MIS-C): https://t.co/Yb…
RT @yoncabulutmd: SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children HLA class I-associated expansion of TRBV11-…
SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children HLA class I-associated expansion of TRBV11-2 T cells in #MISC @ArditiMd @BrodinPetter @VirusesImmunity @EricTopol @jclinicalinvest https://t.co/3dv8rP6lZw Commentary: https://
RT @jclinicalinvest: Just Published: SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children (MIS-C): https://t.co/Yb…
RT @jclinicalinvest: Just Published: SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children (MIS-C): https://t.co/Yb…
RT @ArditiMd: JCI Commentary published for our JCI article on SARS-CoV2 Superantigen in MIS-C , and expansion of TRBV11-2 T cells associate…
RT @ArditiMd: JCI Commentary published for our JCI article on SARS-CoV2 Superantigen in MIS-C , and expansion of TRBV11-2 T cells associate…
RT @ArditiMd: JCI Commentary published for our JCI article on SARS-CoV2 Superantigen in MIS-C , and expansion of TRBV11-2 T cells associate…
RT @ArditiMd: JCI Commentary published for our JCI article on SARS-CoV2 Superantigen in MIS-C , and expansion of TRBV11-2 T cells associate…
RT @ArditiMd: JCI Commentary published for our JCI article on SARS-CoV2 Superantigen in MIS-C , and expansion of TRBV11-2 T cells associate…
RT @ArditiMd: JCI Commentary published for our JCI article on SARS-CoV2 Superantigen in MIS-C , and expansion of TRBV11-2 T cells associate…
RT @ArditiMd: JCI Commentary published for our JCI article on SARS-CoV2 Superantigen in MIS-C , and expansion of TRBV11-2 T cells associate…
RT @ArditiMd: JCI Commentary published for our JCI article on SARS-CoV2 Superantigen in MIS-C , and expansion of TRBV11-2 T cells associate…
RT @ArditiMd: JCI Commentary published for our JCI article on SARS-CoV2 Superantigen in MIS-C , and expansion of TRBV11-2 T cells associate…
RT @ArditiMd: JCI Commentary published for our JCI article on SARS-CoV2 Superantigen in MIS-C , and expansion of TRBV11-2 T cells associate…
JCI Commentary published for our JCI article on SARS-CoV2 Superantigen in MIS-C , and expansion of TRBV11-2 T cells associated with permissive HLA -I ( A02,B35 and C04).
RT @jclinicalinvest: Just Published: SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children (MIS-C): https://t.co/Yb…
Just Published: SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children (MIS-C): https://t.co/Yb3Xw7cOxM A #Commentary by Theodore Kouo and Worarat Chaisawangwong @HopkinsMedicine Related article: https://t.co/iMFa6LWhST https://t.co
RT @fitterhappierAJ: There is a selective expansion of T cells in cov2: Read to see how this happens and consider why this is important. h…
RT @CyrilPedia: 'we characterized the TCR repertoire of MIS-C patients and found a profound expansion of TRBV11-2, with up to 24% of clonal…
RT @fitterhappierAJ: There is a selective expansion of T cells in cov2: Read to see how this happens and consider why this is important. h…
Thank you for highlighting.
RT @CyrilPedia: 'we characterized the TCR repertoire of MIS-C patients and found a profound expansion of TRBV11-2, with up to 24% of clonal…
RT @CyrilPedia: 'we characterized the TCR repertoire of MIS-C patients and found a profound expansion of TRBV11-2, with up to 24% of clonal…
Is this telling us new immunology?...really need to think about that junctional diversity...
RT @CyrilPedia: 'we characterized the TCR repertoire of MIS-C patients and found a profound expansion of TRBV11-2, with up to 24% of clonal…
RT @CyrilPedia: 'we characterized the TCR repertoire of MIS-C patients and found a profound expansion of TRBV11-2, with up to 24% of clonal…
RT @fitterhappierAJ: There is a selective expansion of T cells in cov2: Read to see how this happens and consider why this is important. h…
RT @CyrilPedia: 'we characterized the TCR repertoire of MIS-C patients and found a profound expansion of TRBV11-2, with up to 24% of clonal…
RT @fitterhappierAJ: There is a selective expansion of T cells in cov2: Read to see how this happens and consider why this is important. h…
RT @fitterhappierAJ: There is a selective expansion of T cells in cov2: Read to see how this happens and consider why this is important. h…
RT @CyrilPedia: 'we characterized the TCR repertoire of MIS-C patients and found a profound expansion of TRBV11-2, with up to 24% of clonal…
RT @CyrilPedia: 'we characterized the TCR repertoire of MIS-C patients and found a profound expansion of TRBV11-2, with up to 24% of clonal…
RT @fitterhappierAJ: There is a selective expansion of T cells in cov2: Read to see how this happens and consider why this is important. h…
RT @fitterhappierAJ: There is a selective expansion of T cells in cov2: Read to see how this happens and consider why this is important. h…
RT @fitterhappierAJ: There is a selective expansion of T cells in cov2: Read to see how this happens and consider why this is important. h…
RT @macroliter: Fascinating & important work by @ArditiMd and coworkers on MIS-C in children. T-cells aren’t always our friends. https://t…
Very interesting work by @ArditiMd
RT @fitterhappierAJ: There is a selective expansion of T cells in cov2: Read to see how this happens and consider why this is important. h…
RT @fitterhappierAJ: There is a selective expansion of T cells in cov2: Read to see how this happens and consider why this is important. h…
RT @fitterhappierAJ: There is a selective expansion of T cells in cov2: Read to see how this happens and consider why this is important. h…
There is a selective expansion of T cells in cov2: Read to see how this happens and consider why this is important. https://t.co/GHU93yYGFI
RT @CyrilPedia: 'we characterized the TCR repertoire of MIS-C patients and found a profound expansion of TRBV11-2, with up to 24% of clonal…
RT @CyrilPedia: 'we characterized the TCR repertoire of MIS-C patients and found a profound expansion of TRBV11-2, with up to 24% of clonal…
'we characterized the TCR repertoire of MIS-C patients and found a profound expansion of TRBV11-2, with up to 24% of clonal T cell space occupied by TRBV11-2 T cells, which correlated with MIS-C severity and serum cytokine levels.' cc @VirusesImmunity ht
RT @ApoThera: HLA class I-associated expansion of TRBV11-2 T cells in Multisystem Inflammatory Syndrome in Children https://t.co/g4GK3QxP3y…