@MarkELindsay I don't think it was fringe. And I don't think your experiment was done correctly.
@Ralph1Waldo @onehorseblind "In silico modeling indicated that polyacidic residues in the Vβ chain encoded by TRBV11-2 (Vβ21.3) strongly interact with the superantigen-like motif of SARS-CoV-2 spike glycoprotein..." https://t.co/83ozhYccyZ
RT @Leo238umi: ④ MHC-Ⅰ, SAgs MHC-II has been shown to be inessential for superAg activation of T cells. “The concept that MHC-I can act a…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @sasswashere: JCI - HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children https://t.co/i…
JCI - HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children https://t.co/iYME77sGEd
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @Leo238umi: 📺 analysis indicates that TRBV11-2 engages in CDR3-independent (Fig.3) interactions w/ ‘the insert 681PRRA’ in #SARSCoV2 “SA…
RT @Leo238umi: ③ Classical bacterial SAgs act via MHC-II. While there is evidence that HLA-II allelic variation determines the severity of…
④ MHC-Ⅰ, SAgs MHC-II has been shown to be inessential for superAg activation of T cells. “The concept that MHC-I can act as a ligand for bacterial SAgs like °SEB has been reported.” Thanks https://t.co/ZNLngZhH8q “https://t.co/o2ISqRTxM4” °https://t.c
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
1) “CD4+ & CD8+ T cells carrying Vβ21.3 (encoded by TRBV11-2) expand (Fig.1I, Tab.2; P5), which implies a superAg-like viral driver of MIS-C and suggests that the virus or its Ags persist.” #SARSCoV2 https://t.co/VK5Aew1tuf Thanks
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @casanova_lab: 3/ A specific feature of MIS-C is the massive expansion of Vbeta21.3 CD4 and CD8 T cells in most patients (https://t.co/D…
Specyficzną cechą MIS-C jest masowa ekspansja limfocytów T CD4 i CD8 Vbeta21.3 u większości pacjentów https://t.co/tRfqcBp77q
RT @casanova_lab: 3/ A specific feature of MIS-C is the massive expansion of Vbeta21.3 CD4 and CD8 T cells in most patients (https://t.co/D…
RT @casanova_lab: 3/ A specific feature of MIS-C is the massive expansion of Vbeta21.3 CD4 and CD8 T cells in most patients (https://t.co/D…
RT @casanova_lab: 3/ A specific feature of MIS-C is the massive expansion of Vbeta21.3 CD4 and CD8 T cells in most patients (https://t.co/D…
3/ A specific feature of MIS-C is the massive expansion of Vbeta21.3 CD4 and CD8 T cells in most patients (https://t.co/Doc6IVZxPj, https://t.co/TnZpoYNaPl, https://t.co/2O8B8iSGgx, https://t.co/SYRdZgazpR, https://t.co/pHx1DQ9Wcf)
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
NK cells (F.4:PRF1,GZMA,GZMH), & to a lesser extent CD8+ T cells (ITGB7, or integrin β 7), exhibit elevated cytotoxicity features w/ potential relevance for tissue damage in * pts. #SARSCoV2 ③PIMS/MIS-C* https://t.co/0RsaUZP0pq Alarmin (DAMPs) https
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
RT @AndrewEwing11: 7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in chil…
7/ Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children. This paper discusses superantigens in terms of MIS-C in children. https://t.co/WjvAPemeZa.
RT @AndrewEwing11: @drclairetaylor Great thread. Thank you! More on immune deficiency here and few tweets after. https://t.co/Gkso3VLBWA
④ MHC-Ⅰ, SAgs MHC-II has been shown to be inessential for superAg activation of T cells. “The concept that MHC-I can act as a ligand for bacterial SAgs like °SEB has been reported.” Thanks https://t.co/ZNLngYZxUi “https://t.co/o2ISqRBoxW” °https://t.c
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: @drclairetaylor Great thread. Thank you! More on immune deficiency here and few tweets after. https://t.co/Gkso3VLBWA
RT @AndrewEwing11: @drclairetaylor Great thread. Thank you! More on immune deficiency here and few tweets after. https://t.co/Gkso3VLBWA
RT @AndrewEwing11: @drclairetaylor Great thread. Thank you! More on immune deficiency here and few tweets after. https://t.co/Gkso3VLBWA
@GidMK @MathStuart Just going to put these out there. https://t.co/aa29FV2a4E https://t.co/eDmGMV5Kg9 https://t.co/Gkso3VLBWA
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: @drclairetaylor Great thread. Thank you! More on immune deficiency here and few tweets after. https://t.co/Gkso3VLBWA
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
📺 analysis indicates that TRBV11-2 engages in CDR3-independent (Fig.3) interactions w/ ‘the insert 681PRRA’ in #SARSCoV2 “SAg-like motif (S: E661-R685)”. https://t.co/9iaSE0wCrg Fig.⬇️: ‘ ’ displays an “ ” that exhibits a high affinity for binding TCRs.
③ Classical bacterial SAgs act via MHC-II. While there is evidence that HLA-II allelic variation determines the severity of streptococcal SAg-mediated diseases, the HLA-I association (①) appears much stronger, potentially explaining the rarity of MIS-C. h
② T cell with TCR Vβ skewing toward TRBV11-2 may not only be expanded, but also activated, thereby driving the cytokine storm in *MIS-C. The HLA association (①↓) could explain why only a small proportion of children develop * after #SARSCoV2 infection. ht
① A profound ‘expansion of TRBV11-2’ in the blood of MIS-C* pts correlated with * severity & serum cytokine levels (Fig.2B), consistent w/ #SARSCoV2 SAg (S:E661-R685) -triggered immune responses. * pts w/ ‘ ’ shared 3 HLA-I alleles (A02,B35,C04) (Fig.
“One pt (MIS-C_severe_14) showed massive expansion of TRBV24-1 (Fig.2A). This pt was 15 years old.” https://t.co/ZNLngYZxUi “TCR repertoire skewing, TBRV11-2 expansion & MIS-C severity correlated with higher levels of circulating shed S1 in MIS-C pts
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: @drclairetaylor Great thread. Thank you! More on immune deficiency here and few tweets after. https://t.co/Gkso3VLBWA
@drclairetaylor Great thread. Thank you! More on immune deficiency here and few tweets after. https://t.co/Gkso3VLBWA
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
📺 analysis indicates that TRBV11-2 engages in CDR3-independent interactions w/ ‘the insert 681PRRA’ in #SARSCoV2 “SAg-like motif (S: E661-R685)”. https://t.co/9iaSE0wCrg Fig.⬇️: ‘ ’ displays an “ ” that exhibits a high affinity for binding TCRs. https://t
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
RT @AndrewEwing11: Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmaf…
Covid et système immunitaire
Some references to consider. https://t.co/sTEDVCeL1o https://t.co/LNxquD3rYP https://t.co/WjvAPelH9C https://t.co/yLcmafd0q6 https://t.co/IQVUrfJcKO https://t.co/KQ74sb3Z0J https://t.co/UkcobCArMW and pop press https://t.co/zK5Wo0D8D4 https://t.co/YVhzCM
RT @RaskinSalmo: Crianças nas quais as células T se expandiram tinham principalmente (mas não somente) antígenos de HLA Classe I A02, B35 e…
RT @LedaDra: Estos artículos hablan del mecanismo productor del SIM-C, semejante al atribuido a la hepatitis aguda grave, mediado por super…
Estos artículos hablan del mecanismo productor del SIM-C, semejante al atribuido a la hepatitis aguda grave, mediado por superantigenos. Ahora qué pasa con las vacunas? 👇 https://t.co/Oq7GAwqFe5 https://t.co/RGmNqBQhW1
RT @RaskinSalmo: Crianças nas quais as células T se expandiram tinham principalmente (mas não somente) antígenos de HLA Classe I A02, B35 e…
RT @RaskinSalmo: Crianças nas quais as células T se expandiram tinham principalmente (mas não somente) antígenos de HLA Classe I A02, B35 e…
RT @ENirenberg: This is indeed seen in SARS-CoV-2, specifically with MIS-C: https://t.co/AZARUXvXY9 But there is something that bothers m…
RT @RaskinSalmo: Crianças nas quais as células T se expandiram tinham principalmente (mas não somente) antígenos de HLA Classe I A02, B35 e…
@DGBassani @RomainMartinIO @fitterhappierAJ "While we did not find any association of MIS-C or TRBV11-2 expansion with HLA-II alleles (Figure 5A), all 4 severe MIS-C patients with TRBV11-2 expansion used HLA-I A02, B35, and C04 alleles (Figure 5, A–C)." h
Crianças nas quais as células T se expandiram tinham principalmente (mas não somente) antígenos de HLA Classe I A02, B35 e C04. Estas estriam geneticamente mais propensas.👇 https://t.co/WbRTil8wMG
RT @yoncabulutmd: SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children HLA class I-associated expansion of TRBV11-…
RT @yoncabulutmd: Predisposition for #MISC , why it is a rare complication @ArditiMd ⚡️ Immune response to viral Superantigen ⚡️Role of H…